CGAS and esophageal squamous cell carcinoma: Furthermore, implications of hub genes with cGAS-STING pathway were estimated in single-cell artificial intelligence (AI) driven-virtual cell and bulk assays.<h4>Results</h4>By utilizing integrative AI and multi-omic pipelines, we proved that the cGAS-STING pathway can guide subgroup stratification and prognostic model construction for ESCC patients.