<h4>Background</h4>Esophageal squamous cell cancer (ESCC) is a malignancy derived from the Esophagus, and dysregulation of the cGAS-STING pathway contributes to ESCC progression.<h4>Method</h4>ESCC bulk-seq dataset GSE38129 was acquired from GEO database and then underwent Limma and WGCNA analysis for the identification of shared DEGs, which were intersected with cGAS-STING pathway gene list and underwent Cox regression analysis for recognized cGAS-STING associated prognostic indicators. The gene discussed is CGAS; the disease is esophageal squamous cell carcinoma.