<h4>Objective</h4>To investigate the specific tumor survival situation of cytoreductive prostatectomy for prostate cancer with lung metastasis.<h4>Methods</h4>Case data of prostate cancer patients diagnosed from 2010 to 2015 were collected from the SEER database (https://seer.cancer.gov/) to obtain age, race, marital status, T stage, N stage, ISUP grade, prostate-specific antigen level (PSA), surgery, radiotherapy, chemotherapy, and survival time. This evidence concerns the gene KLK3 and Familial prostate cancer.