The main objective of the current study was to investigate possible modulation of the NLRP3 inflammasome and monocyte chemokine receptors in individuals with obesity following HIIT.<h4>Subjects/methods</h4>In this randomized trial, we included individuals with obesity (n = 109), who have not exercised in the last six months, of both sexes, aged between 18 and 60 years.<h4>Interventions</h4>Participants were divided into a trained group, which performed three weekly HIIT sessions over eight weeks, and an untrained group (control). The gene discussed is NLRP3; the disease is Obesity.