Differentially expressed genes interaction analysis [CASP-1, ASC (PYCARD), IL-6, CCR2, CXC3CR1 and CCR5] revealed interaction with NLRP3 nflammasome genes.<h4>Conclusions</h4>Eight weeks of HIIT can modulate some components involved in the NLRP3 inflammasome, as well as monocyte chemokine receptors, in individuals with obesity, suggesting an improvement in the control of inflammatory status.<h4>Trial registration</h4>Brazilian Registry of Clinical Trials - ReBEC number RBR-8vfxfqd). This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.