Hence, the current study aimed to investigate the pathogenesis of EMT, which focus on the function of Epithelial Splicing Regulatory Protein 1 (ESRP1) in regulating EMT.<h4>Methods</h4>The present study utilized bleomycin (BLM) to establish mouse models of IPF. The gene discussed is ESRP1; the disease is idiopathic pulmonary fibrosis.