In terms of prognostic factors, TBIL (total bilirubin) and PT (prothrombin time) were identified as independent risk factors for 90-day mortality in HBV-ACLF patients, while WBC, TBIL, and PT were associated with 90-day mortality in ALD-ACLF patients.<h4>Conclusion</h4>Patients with ALD-ACLF typically present with a higher prevalence of comorbidities, such as ascites and infections, compared to those with HBV-ACLF. The gene discussed is F2; the disease is infection.