While TNF and C1Q have been extensively investigated in glaucoma-relevant model systems, the role of IL1A in RGCs is not well defined.<h4>Methods</h4>Eyes of 2-4 month-old C57BL/6J mice or mice deficient in either <i>Jun</i> or <i>Sarm1</i> were intravitreally injected with IL1A alone, TNF alone, or IL1A and TNF together. The gene discussed is SARM1; the disease is glaucoma.