The results of heterogeneity and pleiotropic tests of MR-Egger intercept showed that there was no heterogeneity or pleiotropy in all data.<h4>Conclusions</h4>This study clarified FLT3 as being involved in the pathogenesis of meningioma from a genetic perspective and genetically predicted lower FLT3L to be causally associated with a higher meningioma risk, implicating FLT3 signalling in meningioma pathogenesis. The gene discussed is FLT3LG; the disease is meningioma.