TG and cyclic hematopoiesis: <i>In vitro</i>, function of <i>Mettl3</i> and molecular mechanisms were further investigated through thyrocyte cells from different species <i>via</i> lentivirus mediated silencing and rescue experiments.<h4>Results</h4>Thyrocyte specific removal of <i>Mettl3</i> caused a typical CH phenotype, with reduced thyroid hormones and body weight.