METTL3 and cyclic hematopoiesis: In this study, we aimed to clarify the new regulatory role of METTL3 in the occurrence and development of CH, and to provide new theoretical support and treatment ideas for the clinical treatment of CH.<h4>Methods</h4>Thyrocyte-specific <i>Mettl3</i> knockout mouse model was constructed and subjected to morphological and functional analyses.