TP53 and pachyonychia congenita: Furthermore, western blot analysis preliminarily validated the potential association between UPR<sup>mt</sup> and both P53 signaling and glycolysis pathways.<h4>Conclusion</h4>Our study systematically characterizes the prognostic and therapeutic implications of MRGs in PC, establishing a 3-gene MRS capable of reliably predicting OS in PC patients and exploring UPR<sup>mt</sup> potential oncogenic mechanisms.