Because γδ T cells can also be redirected by BLN, we systematically studied BLN-driven effector functions <i>in vitro</i> in conventional αβ and unconventional γδ T cells from healthy donors.<h4>Materials and methods</h4>We evaluated cytotoxicity and cytokine/effector release in freshly isolated and <i>in vitro</i>-expanded αβ and γδ T cells from healthy adults against CD19<sup>+</sup> BCP-ALL cell lines (NALM-6, HAL-01), and profiled dynamic phenotypic alterations by multiparametric flow cytometry.<h4>Results</h4>CD19<sup>+</sup> targets were consistently reduced in the presence of BLN. The gene discussed is CD19; the disease is acute lymphoblastic leukemia.