Importantly, reduced overall survival in clear cell carcinoma was linked to PVR expression, and rare cases with high levels consistently progressed to metastatic disease.<h4>Conclusion</h4>In renal tumors, a preliminary subtype-specific pattern emerged: PVR expression was generally low in clear cell carcinoma but enriched in papillary carcinoma. The gene discussed is PVR; the disease is thyroid gland papillary carcinoma.