Although it is broadly expressed across many malignancies, its prognostic and predictive value in renal and bladder cancers remains underexplored.<h4>Methods</h4>Quantitative immunohistochemical analysis of PVR expression was performed in tumor tissue from patients with bladder cancer or renal cell carcinoma, including clear cell and papillary subtypes. Here, PVR is linked to hereditary clear cell renal cell carcinoma.