Over time, she exhibited borderline non-verbal cognitive functioning, persistent speech impairment, and was subsequently diagnosed with comorbid Attention Deficit Hyperactivity Disorder.<h4>Discussion</h4>This study identifies shared neurobehavioral features of idiopathic Autism Spectrum Disorder (ASD) associated with <i>de novo</i> LoF mutations in ARHGAP32 and reinforces the involvement of RhoGAP family proteins in neurodevelopmental disorders. The gene discussed is ARHGAP32; the disease is autism spectrum disorder.