By analyzing the pathways of ulcerative colitis and colon cancer, we identified a common risk pathway - Vascular Endothelial Growth Factor (VEGF).<h4>Methods</h4>Based on the Gene Set Variation Analysis (GSVA) scores of the VEGF pathway in colon cancer patients, we divided them into three groups: high, medium, and low. Here, VEGFA is linked to malignant colon neoplasm.