This study explored the association of <i>SLCO1B1</i> c.521T>C and c.388A>G variants with coronary heart disease (CHD) risk, and evaluated the lipid-lowering efficacy and safety of standard-dose statins in subjects aged >75 years to provide evidence for geriatric clinical statin use.<h4>Methods</h4>A retrospective cohort study analyzed 6,146 individuals who were genotyped <i>SLCO1B1</i> variants c.521T>C and c.388A>G. The gene discussed is SLCO1B1; the disease is coronary artery disorder.