Correlation analysis demonstrated weak and non-significant relationships between CD4 + counts and haemoglobin levels (<i>r </i>= -0.095, <i>P </i>= 0.530), gender (<i>r </i>= -0.126, <i>P </i>= 0.403), and age (<i>r </i>= 0.193, <i>P </i>= 0.198).<h4>Conclusion</h4>These findings highlight significant reduced CD4 levels in SCD patients during crises, underscoring the need for regular immunological monitoring. Here, CD4 is linked to Schnyder corneal dystrophy.