Daily Fj administration (10 μg/g BW) significantly improved hepatic lipid metabolism and regulated Keap1/Nrf2 signaling pathway, ultimately mitigating hepatic ferroptosis.<h4>Conclusion</h4>These findings demonstrate that probiotic fermentation as a strategic approach to develop postbiotic-based functional beverages for mitigating alcohol-induced liver injury, offering translational potential against ALD progression. Here, KEAP1 is linked to alcohol drinking.