We have evaluated the levels of splicing factors mRNA (HNRNPA1, HNRNPA2B1, SRSF1, SRSF2, SRSF3, BRM and SAM68) as well as HPV16 E6 and E6*I mRNAs by qPCR in HNSCC as well as in SCC152 and SCC154 cell lines. The gene discussed is HNRNPA2B1; the disease is head and neck squamous cell carcinoma.