The SRSF3, BRM and SAM68 transcripts were significantly higher in HPV-positive compared to HPV-negative HNSCC (<i>p</i> < 0.05), and SAM68 with HPV16 E6*I transcripts concordantly high in both HNSCC and cell lines (<i>r</i> = 0.7). The gene discussed is KHDRBS1; the disease is head and neck squamous cell carcinoma.