In longitudinal analyses, participants with higher baseline NT-proBNP had faster declines in eGFR, with a 10-year decline of -1.37 (-1.77, -0.98) ml/min/1.73m<sup>2</sup> eGFRcr-cys per 1 SD increase, and higher CKD incidence. Here, NPPB is linked to chronic kidney disease.