Furthermore, we demonstrated that HNF1B exerts its tumor-suppressive roles by concurrently inhibiting the mitogen-activated protein kinase (MAPK) signaling pathway and the epithelial-mesenchymal transition (EMT) process.<h4>Conclusion</h4>Our study unveils a novel epigenetic mechanism in bladder cancer, whereby promoter hypermethylation silences HNF1B, thereby promoting tumor progression through activation of the MAPK pathway. This evidence concerns the gene WNK2 and urinary bladder cancer.