These effects were more pronounced following epithelial-mesenchymal transition (EMT) induction with TGF-β1 (p < 0.01).<h4>Conclusion</h4>Taken together, the obtained results indicate that SPX could be a regulator of kidney cell function and may be a potential therapeutic target in the treatment of kidney diseases in dogs and cats. This evidence concerns the gene TGFB1 and kidney disorder.