LEP and Hepatic fibrosis: From the STRING database, the proteins are at least partially biologically connected, as a group with leptin and vitamin D explaining the promiscuous nature of leptin and vitamin D. This emphasized the role of leptin and vitamin D in accumulation and increased synthesis of extracellular matrix proteins that incorporated in the pathogenesis of liver fibrosis, and showed that the leptin and vitamin D are involved in the pathogenesis process where the total proteins are involved.