FMR1 and experimental autoimmune encephalomyelitis: This study aimed to elucidate a novel post-transcriptional regulatory mechanism controlling NLRP3 expression in microglia under lipopolysaccharide (LPS) stimulation.<h4>Methods</h4>The experimental autoimmune encephalomyelitis (EAE) mouse model of MS was established and divided into four groups: Sham, EAE, EAE + Lv-con (control lentivirus), and EAE + Lv-FMR1 (FMR1-overexpressing lentivirus).