The present study aimed to evaluate the expression of HML-2 elements using RNA-sequencing data in paired tumor and normal intestinal tissue samples from 63 patients with CRC to identify patterns of the retrotransposons' activity in different molecular subtypes (CMSs).<h4>Methods</h4>RNA-sequencing and DNA methylation data were analyzed for paired CRC and normal tissue samples. This evidence concerns the gene CLEC10A and neoplasm.