Associations of HML-2 expressions with differentially expressed genes in which they are located were found, and for a number of such genes an inverse relationship between the expression level and the methylation level of their promoters were demonstrated, and data on the involvement in the pathogenesis of CRC were described: <i>CR1</i>, <i>CD48</i>, <i>TTLL3</i>, <i>ABCC2</i> and <i>ZNF420</i>. This evidence concerns the gene CD48 and colorectal carcinoma.