Lung hydroxyproline content was also markedly decreased, indicating attenuation of extracellular matrix accumulation.<h4>Conclusions</h4>Short-term neutralization of microbiota-derived corisin rapidly alleviates inflammation, epithelial injury, and fibrotic remodeling in advanced TGF-β1-induced pulmonary fibrosis. Here, TGFB1 is linked to pulmonary fibrosis.