However, the role of DPN in the attenuation of AD-associated cognitive dysfunctions through regulation of KCC2 functions has not yet been investigated.<h4>Objectives</h4>The present study was designed to investigate the role of DPN against amyloid-β oligomer-induced AD in mice.<h4>Methods</h4>In this study, a total of six groups with eight male Swiss albino mice per group were used. Here, SLC12A5 is linked to Alzheimer disease.