Expression of diabetes-related genes (PI3K, Akt) in the liver, inflammation-related genes (IL-6, IL-10, IL-1β, IL-4) in the colon, cannabinoid receptors (CB1, CB2) in both tissues, and changes in gut microbiota composition were evaluated using quantitative PCR.<h4>Results</h4>Compared to the T2DM-PBS group, administration of <i>B. This evidence concerns the gene CNR1 and type 2 diabetes mellitus.