Therefore, early identification and management of sepsis can improve outcomes.<h4>Objective</h4>All the studies aimed to find out novel markers for early clinical recognition of sepsis.<h4>Methods</h4>We retrospectively analyzed 1,245 results of the detection of intrinsic coagulation factors (FVIII, FIX, FXI, and FXII). This evidence concerns the gene F8 and Sepsis.