Finally, three receiver operating characteristic (ROC) curves were plotted separately for patients of three diseases versus 20 healthy normal subjects.<h4>Results</h4>Our analysis of 1,245 clinical specimens revealed that the co-occurrence of elevated FVIII (>150%) and reduced FXII (<50%) was most prevalent in three diseases: cirrhosis (<i>n</i> = 8), pneumonia (<i>n</i> = 5), and sepsis (<i>n</i> = 4). The gene discussed is F8; the disease is pneumonia.