F8 and Sepsis: Critically, ROC analyses demonstrated that the FVIII/FXII ratio exhibited superior diagnostic performance for sepsis (AUC = 0.920), outperforming both FVIII (AUC = 0.710) and FXII (AUC = 0.840) alone.<h4>Conclusion</h4>CD163 and the FVIII/FXII ratio can be used as novel markers for early clinical recognition of sepsis.