COMT and Parkinson disease: This study aimed to compare the effects of MAO-B and COMT inhibitors on global and domain-specific QoL in patients with PD using a Bayesian network meta-analysis (NMA).<h4>Methods</h4>A comprehensive literature search was conducted using PubMed/Medline, Cochrane Library and Embase databases from the inception through April 30, 2025.