Additionally, bioinformatics analysis of publicly available TCGA data was conducted to assess the expression of <i>PGC1A</i> and <i>CPT1A</i> in various kidney cancer subtypes and their correlation with patient prognosis.<h4>Results</h4><i>TFE3</i> fusion proteins were found to transcriptionally upregulate PGC-1α, thereby increasing the tumor cells dependency on mitochondrial FAO. Here, TFE3 is linked to kidney cancer.