Machine learning highlighted six key diagnostic genes-BASP1, LITAF, NAMPT, PHACTR1, PLAUR, PPIF-with BASP1 showing the strongest performance (AUC = 0.935).<h4>Conclusions</h4>Pyroptosis is highly active in specific immune and epithelial cells in IBD. This evidence concerns the gene PHACTR1 and inflammatory bowel disease.