The combined ROC analysis of CD8<sup>+</sup> T cell counts, CD4<sup>+</sup> T cell counts, and the EGRIS score demonstrated good discriminative ability for identifying GBS patients who required mechanical ventilation, with an AUC of 0.87 (95% CI, 0.772-0.971, <i>P</i> < 0.001). This evidence concerns the gene CD4 and Guillain-Barre syndrome.