RNA-seq analysis revealed that hypothalamic <i>CYTB</i>, <i>ATP6</i>, <i>COX</i>, <i>ABLIM1</i>, and <i>ABI3</i> were significantly upregulated in IM group, whereas <i>SHISA7</i> and <i>PTPRO</i> were significantly downregulated, with notable enrichment in prion disease, oxidative phosphorylation, and thermogenesis pathways. Here, PTPRO is linked to prion disease.