This study investigates the role of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a potential therapeutic target and immune-checkpoint enzyme in ccRCC.<h4>Methods</h4>ENPP3 expression and its link to hypoxia and prognosis were analyzed in ccRCC. Here, ENPP3 is linked to nonpapillary renal cell carcinoma.