In silico analyses evaluated protein-protein interactions, gene-gene networks, epigenetic modifications, and correlations with immune cell infiltration and immunomodulatory molecules using publicly available datasets.<h4>Results</h4>SOX9, TNFAIP3, and FOSL2 were identified as interconnected regulators within NF-κB and TGF-β pathways, enriched in inflammatory and infection-related processes, and epigenetically modulated via promoter hypermethylation and histone remodeling. This evidence concerns the gene NFKB1 and infection.