In all cases, luteal phase support is imperative and should ideally be provided by hCG injections to optimize corpus luteum functions.<h4>Conclusion</h4>When pulsatile GnRH therapy is not available, and to ensure the effective treatment of female infertility due to FHA (with or without PCOS) or hypothalamic CHH, we advise physicians to optimise stimulation with exogenous gonadotropins according to the cause of hypothalamic hypogonadotropic hypogonadism. This evidence concerns the gene GNRH1 and female infertility.