GNRH1 and cartilage-hair hypoplasia: There is extensive literature accounting for a high ovulation rate and consequently high pregnancy and birth rates per cycle, with a lower risk of adverse outcomes.<h4>Results</h4>In this review, based on clinical evidence and published studies, we provide recommendations for the alternative treatment of infertility in women with congenital hypothalamic hypogonadotropic hypogonadism (CHH) and FHA (with or without PCOM), until pulsatile GnRH therapy becomes available again or in countries where this device is not marketed.