Methylation-specific polymerase chain reaction and reverse-transcription polymerase chain reaction analyses revealed significantly higher methylation of the promoter region of ZNF382 (p < 0.0001), whereas ZNF382 mRNA expression was significantly lower (p < 0.01) in DLBCL cells compared with those in reactive hyperplastic lymph node tissues. The gene discussed is ZNF382; the disease is diffuse large B-cell lymphoma.