However, the underlying mechanisms remain unknown.<h4>Aims</h4>To investigate the association between DNA methylation of the promoter region of ZNF382 and ZNF382 expression with the occurrence and progression of DLBCL and to analyze the clinical significance of ZNF382 in DLBCL.<h4>Methods and results</h4>DLBCL cell lines and reactive hyperplastic lymph node tissues were used as the experimental subjects. This evidence concerns the gene ZNF382 and diffuse large B-cell lymphoma.