NPPB and hydrops fetalis: CoDE-HF was more accurate than guideline-recommended thresholds across all age groups, with NPV and PPV ranging from 96.4% to 99.5% (93.8-99.8% CIs) and 81.1% to 84.2% (74.7-90.4% CIs), respectively.<h4>Conclusion</h4>The diagnostic performance of guideline-recommended thresholds of NT-proBNP varies significantly with age.