<h4>Introduction</h4>This study aimed to evaluate the diagnostic value of lipocalin 2 (LCN2) and microRNA-8078 (miR-8078) in congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH).<h4>Methods</h4>Seventy-six patients were diagnosed with CHD-PAH according to established clinical guidelines (including mean pulmonary arterial pressure (mPAP), pulmonary artery wedge pressure, and pulmonary vascular resistance) via right heart catheterization. Here, LCN2 is linked to congenital heart disease.