This study aimed to develop and validate the Adjusted Ferritin Inflammation Index (AFII), a novel composite score integrating ferritin/C-reactive protein (CRP) ratio and albumin levels, to improve mortality risk stratification in HF patients.<h4>Methods</h4>This retrospective cohort study included 322 patients with HF and reduced or mildly reduced ejection fraction (HF with reduced ejection fraction: left ventricular ejection fraction ≤40%; HF with mildly reduced ejection fraction: left ventricular ejection fraction 41%-49%). This evidence concerns the gene CRP and hydrops fetalis.