<h4>Aim</h4>To investigate the inhibitory effect of luteolin on proliferative vitreoretinopathy (PVR) and explore its potential mechanism.<h4>Methods</h4>Human retinal pigment epithelial ARPE-19 cells were treated with luteolin (0-50 μM) to assess its effects on cell viability, migration, and TGF-β2-induced epithelial-mesenchymal transition (EMT). Here, TGFB2 is linked to proliferative vitreoretinopathy.