However, EZH2-associated immune programs in bulk cohorts and their corresponding cell-type-specific features in single-cell RNA sequencing (scRNA-seq) data have not been systematically delineated in advanced PCa.<h4>Methods</h4>We integrated bulk RNA-seq and scRNA-seq to map EZH2-associated transcriptional and immune features in PCa. Here, EZH2 is linked to posterior cortical atrophy.