No statistically significant association was observed between tumor site and E-cadherin expression. Reduced or absent E-cadherin expression was significantly associated with advanced tumor stage (p=0.002), higher nodal stage (p=0.018), and perineural invasion (p=0.008).<h4>Conclusion</h4>E-cadherin dysregulation is strongly associated with histological tumor grade, adenocarcinoma type, tumor stage, nodal metastasis, and perineural invasion in GI adenocarcinomas. This evidence concerns the gene CDH1 and neoplasm.