Multivariate logistic regression analyzed the link between ApoE polymorphisms and CAD risk in populations at middle and high altitudes.<h4>Results</h4>The data revealed significant differences in <i>APOE</i> gene ε3ε4 and ε4ε4 genotypes, as well as ε4 allele frequencies, 1256 CAD and non-CAD cases (<i>p</i> < 0.05). Here, APOE is linked to coronary artery disorder.