VEGFA and diabetic macular edema: <h4>Objective</h4>This study aimed to systemically compare the predictive value of systemic inflammatory indicators, renal function, and optical coherence tomography (OCT)-derived morphological characteristics for the short-term response to anti-vascular endothelial growth factor (anti-VEGF) therapy in patients with diabetic macular edema (DME), and to clarify their relative importance.<h4>Methods</h4>A single-center retrospective observational study was conducted involving 81 DME patients who completed three monthly loading doses of anti-VEGF therapy.