Supplementation of CTRP4, but not receptor for advanced glycation end-products (RAGE)- and toll-like receptor 4 (TLR4)-binding incompetent CTRP4 mutant, either through adipose tissue transplantation from wild-type mice or intravenous injection of recombinant protein, attenuated atherosclerosis in CTRP4<sup>‒/‒</sup>/ApoE<sup>‒/‒</sup> mice. This evidence concerns the gene TLR4 and atherosclerosis.