Conversely, YWHAH knockdown impaired NPC cell migration and upregulated IL-6/IL-8 expression, effects that were partially rescued by TNF-α treatment.<h4>Conclusion</h4>Integration of multi-omics data facilitated the identification of YWHAH as a METTL14-regulated gene, which plays a pivotal role in the NPC immune microenvironment. The gene discussed is TNF; the disease is nasopharyngeal carcinoma.