The post-transcriptional regulatory role was further validated in NPC cells with overexpression or knockdown of METTL14, or in cells with YWHAH silenced.<h4>Results</h4>B cells were identified as the primary senders to the TNF pathway, with epithelial and myeloid cells acting as influencers and receivers. The gene discussed is TNF; the disease is nasopharyngeal carcinoma.