Conversely, in PWH, impaired HVPG regression was associated with sVCAM-1 (AMR = 1.58; q=0.096), and a more focused activation within EM (HLA-DR+, AMR = 1.08; q=0.030) and TemRA (CD38+HLA-DR+, AMR = 1.12; q=0.030) CD4+ T-cells.<h4>Discussion</h4>HIV coinfection fundamentally reshapes the immunological landscape of post-cure portal hypertension recovery. This evidence concerns the gene CD38 and portal hypertension.