The role of ADAMTS5 in tumor growth and metastasis was validated in nude mice using subcutaneous and tail vein injections.<h4>Results</h4>A regulatory axis lncRNA (MSTRG.10627.1)-miRNA (miR-142-5p)-mRNA (ADAMTS5) with the highest correlation coefficient was screened out. Here, ADAMTS5 is linked to neoplasm.