SOD1 and early-onset autosomal dominant Alzheimer disease: In vivo studies showed that these flavonoids reduced malondialdehyde (MDA) levels in the cerebral cortex of Alzheimer's disease (AD) mice, enhanced the activities of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT), mitigated oxidative damage, and improved cognitive dysfunction in AD mice.