Associations between MRPL23 expression and clinicopathological features, as well as overall survival, were analyzed using survival statistics.<h4>Results</h4>MRPL23 expression was significantly higher in NSCLC tissues than in normal lung tissues (p < 0.0001), with particularly elevated levels observed in squamous cell carcinoma. The gene discussed is MRPL23; the disease is non-small cell lung carcinoma.